Covid-19: How Native Americans led the way in the US vaccination effort
نویسندگان
چکیده
The direct and indirect efferent pathways from striatum ultimately reconverge to influence basal ganglia output nuclei, which in turn regulate behavior via thalamocortical brainstem motor circuits. However, the distinct contributions of these two shaping are not well understood. We investigated processes using selective optogenetic control pathways, combination with single-unit recording nucleus substantia nigra pars reticulata (SNr) mice. Optogenetic activation striatal pathway projection neurons produced diverse cellular responses SNr neurons, stimulation each eliciting both excitations inhibitions. Despite this response heterogeneity, effectiveness producing movement initiation correlated selectively subpopulation inhibited neurons. In contrast, effective pathway-mediated suppression was most strongly influenced by excited Our results support theory that key serve as an inhibitory gate over can be opened or closed respectively.
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ژورنال
عنوان ژورنال: BMJ
سال: 2021
ISSN: ['0959-8138']
DOI: https://doi.org/10.1136/bmj.n2168